Tetrodotoxin Framework Construction from Linear Substrates Utilizing a Hg(OTf)<sub>2</sub>-Catalyzed Cycloisomerization Reaction: Synthesis of the Unnatural Analogue 11-<i>nor</i>-6,7,8-Trideoxytetrodotoxin
نویسندگان
چکیده
In this contribution, we propose a new synthetic approach to tetrodotoxin (TTX), one of the most famous marine toxins that, after first preparing functionalized linear substrate, forms cyclohexane core from substrate utilizing our mercuric triflate (Hg(OTf)2)-catalyzed cycloisomerization reaction. The concept was applied synthesis 11-nor-6,7,8-trideoxyTTX and 11-nor-4,9-anhydro-6,7,8-trideoxyTTX, which are unnatural TTX analogues, demonstrating validity approach.
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2021
ISSN: ['1523-7060', '1523-7052']
DOI: https://doi.org/10.1021/acs.orglett.1c00125